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So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER

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146 Mice with -cell-specific disruption of Sel1L-HRD1 develop early-onset diabetes and glucose intolerance, reflecting impaired insulin secretion and -cell dysfunction

Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-l-cysteine

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Glutathione plays a pivotal role in most key physiological functions including but not limited to maintenance of cellular redox, neutralising free radicals, cell cycle regulation, proliferation, apoptosis, xenobiotic metabolism, and the recycling of other cellular antioxidants such as Vitamins C and E